Abstract Background Significant heterogeneity exists among people who use drugs (PWUD).We identify distinct profiles of syringe service program (SSP) clients to (a) evaluate differential risk factors across subgroups and (b) inform harm reduction programming.Methods Latent class analysis (LCA) was applied to identify subgroups of participants (N =
Based on the laboratory large scale model test of the stepped Cleanser reinforced soil retaining wall (RSRW), the discrete element numerical model of stepped RSRW is set up by particle flow code.The displacement of particles, stress distribution, force chain distribution, and potential failure surface of the stepped RSRW are analyzed by simulating
When investigating a fire type event, one has to have in mind that maybe the most important aspect is the identification of the source of ignition.Nowadays, commercial and open-source software are available and can be used during such investigations.The fire field model - Fire Dynamics Simulator (FDS) is one of the most popular numerical model Door
During tumor development and progression, intrinsic and extrinsic factors trigger endoplasmic reticulum (ER) stress and the unfolded protein response, resulting in the increased expression of molecular chaperones to cope with the stress and maintain tumor cell survival.Heat shock protein (HSP) GRP94, also known as GP96, is an ER paralog of HSP90 an